دانلود کتاب Handbook of atypical parkinsonism

Improved diagnostic sophistication is increasingly enabling neurologists to differentiate between Parkinson's disease and other atypical parkinsonism (AP), such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. The Handbook of Atypical Parkinsonism is a comprehensive survey of all diseases of this category, providing an authoritative guide to the recognition, diagnosis and management of these disorders. Each chapter follows a common structure, commencing with the full basic science of the disorder under consideration, followed by descriptions of the clinical picture and differential diagnosis. Subsequent chapters discuss current and future therapeutic approaches to these difficult conditions. Written and edited by leading practitioners in the field, clinicians in neurology and other specialties will find this book essential to the understanding and diagnosis of this complex group of disorders ''Improved diagnostic sophistication is increasingly enabling neurologists to differentiate between Parkinson's disease and other atypical parkinsonism (AP), such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. The Handbook of Atypical Parkinsonism is a comprehensive survey of all diseases of this category, providing an authoritative guide to the recognition, diagnosis and management of these disorders. Each chapter follows a common structure, commencing with the full basic science of the disorder under consideration, followed by descriptions of the clinical picture and differential diagnosis. Subsequent chapters discuss current and future therapeutic approaches to these difficult conditions. Written and edited by leading practitioners in the field, clinicians in neurology and other specialties will find this book essential to the understanding and diagnosis of this complex group of disorders''--Provided by publisher.  Read more... Cover -- Half-title -- Title -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1 Introduction -- References -- Chapter 2 Parkinsons disease and the spectrum of Lewy body disease -- History -- Clinical findings -- Central feature -- Core features -- Suggestive features -- Supportive features -- Overlapping symptoms across the Lewy body disorders -- Natural history -- Laboratory investigations -- Genetics -- Pathology -- Management -- Treatment of cognitive impairment -- Treatment of neuropsychiatric features -- Treatment of motor dysfunction -- Treatment of other symptoms -- Conclusions -- References -- Chapter 3 Multiple system atrophy -- Introduction -- Epidemiology -- Natural history and progression -- Investigations -- Autonomic function tests -- Cardiovascular autonomic function tests -- Urological work-up -- Sphincter electromyography -- Cerebrospinal fluid investigations -- Neuroendocrinological investigations -- Neuroimaging -- Structural imaging -- Pathology -- Etiopathogenesis -- Environmental factors -- Genetics -- Animal models -- Therapies -- Principles of management -- Neuroprotective therapy -- Symptomatic therapy -- Palliative care -- Pragmatic management -- References -- Chapter 4 Progressive supranuclear palsy -- Historical review -- Morphological features -- Genetics -- Clinical picture -- Presenting features -- Core characteristics of the disease -- Clinical variants -- Clinical diagnostic criteria -- Time course of the disease -- Epidemiology -- Investigations -- Introduction -- Computerized tomography -- Routine magnetic resonance imaging -- Diffusion-weighted imaging -- Magnetic resonance volumetry -- Functional imaging -- Neurophysiology -- Other investigations -- Treatment -- General approach -- Treatment of parkinsonism -- Treatment of other clinical features -- Neuroprotection trials -- Conclusions -- References -- Chapter 5 Corticobasal degeneration -- Introduction and history -- Epidemiology -- Pathology -- Genetics -- Animal models -- Clinical findings -- Corticobasal syndrome -- Clinical features of corticobasal degeneration -- Natural history -- Investigations -- Neuropsychological testing -- Neuroimaging -- Electrophysiology -- Management -- Pharmacological therapies -- Physical therapy and speech therapy -- Surgery -- Palliative therapy -- Conclusion and future directions -- References -- Chapter 6 Parkinsonism other causes -- Drug-induced parkinsonism -- Toxic causes of parkinsonism -- Metabolic disorders causing parkinsonism -- Infection-related parkinsonism -- Structural lesions causing parkinsonism -- Degenerative diseases causing parkinsonism -- Miscellaneous causes of parkinsonism -- Conclusion -- References -- Chapter 7 The differential diagnosis of parkinsonism: A clinical approach -- Introduction -- Motor symptoms -- Tremor -- Bradykinesia and akinesia -- Rigidity -- Balance and gait disorders -- Other motor symptoms -- Non-motor symptoms -- Olfactory abnormalities -- Sleep abnormalities -- T$30120