دانلود کتاب Reactive Drug Metabolites

Content: Chapter 1 Origin and Historical Perspective on Reactive Metabolites (pages 1–12): Chapter 2 Role of Reactive Metabolites in Genotoxicity (pages 13–42): Chapter 3 Bioactivation and Inactivation of Cytochrome P450 and Other Drug?Metabolizing Enzymes (pages 43–70): Chapter 4 Role of Reactive Metabolites in Drug?Induced Toxicity – The Tale of Acetaminophen, Halothane, Hydralazine, and Tienilic Acid (pages 71–92): Chapter 5 Pathways of Reactive Metabolite Formation with Toxicophores/?Structural Alerts (pages 93–129): Chapter 6 Intrinsically Electrophilic Compounds as a Liability in Drug Discovery (pages 131–143): Chapter 7 Role of Reactive Metabolites in Pharmacological Action (pages 145–183): Chapter 8 Retrospective Analysis of Structure–Toxicity Relationships of Drugs (pages 185–202): Chapter 9 Bioactivation and Natural Products (pages 203–224): Chapter 10 Experimental Approaches to Reactive Metabolite Detection (pages 225–240): Chapter 11 Case Studies on Eliminating/Reducing Reactive Metabolite Formation in Drug Discovery (pages 241–268): Chapter 12 Structural Alert and Reactive Metabolite Analysis for the Top 200 Drugs in the US Market by Prescription (pages 269–312): Chapter 13 Mitigating Toxicity Risks with Affinity Labeling Drug Candidates (pages 313–334): Chapter 14 Dealing with Reactive Metabolite–Positive Compounds in Drug Discovery (pages 335–355): Chapter 15 Managing IADRs – a Risk–Benefit Analysis (pages 357–375):