دانلود کتاب Bioseparation and Bioprocessing: Biochromatography, Membrane Separations, Modeling, Validation

Rapid developments in biotechnology create a demand for practical, up-to-date reviews written by and for experts in industry. This compact handbook provides all relevant up-to-date information on important bioseparation and bioprocessing techniques that are actively applied in the biotechnology industries. The handbook presents an applications-orientated overview on - case studies and general strategies for quality control and characterization - detailed guidelines on developing economic and technically feasible bioseparation schemes - strategies and methods for intracellular bioproduct release - chromatographic and membrane downstream processes used in biotechnology - applications of modern non-invasive methods such as neural networks for on-line estimation and control of fermentation variables on an industrial scale - a practical, commercially-relevant guide to biosafety and many more aspects which are indispensible for present and future industrial success.Content: Chapter 1 Simulated Moving Bed (SMB): Some Possible Applications for Biotechnology (pages 1–39): Roger M. NicoudChapter 2 Systematic Development of Chromatographic Processes Using Perfusion Chromatography Technology (pages 41–64): Scott Fulton and Thomas LondoChapter 3 Hydrophobic Interaction Chromatography of Proteins (pages 65–88): Eric GrundChapter 4 Displacement Chromatography: Application to Downstream Processing in Biotechnology (pages 89–112): Ruth FreitagChapter 5 Affinity Chromatography (pages 113–124): Jim PearsonChapter 6 Large?Scale Chromatography: Design and Operation (pages 125–143): C. J. A. DavisChapter 7 Radial Flow Chromatography: Developments and Application in Bioseparations (pages 145–156): Denise M. WallworthChapter 8 Enhanced Diffusion Chromatography and Related Sorbents for Biopurification (pages 157–198): Egisto Boschetti and John L. CoffmanChapter 9 Expanded Bed Adsorption Chromatography (pages 199–226): Rolf Hjorth, Patrik Leijon, Ann?Kristin Barnfield Frej and Christina JagerstenChapter 10 Application of Membrane Bioseparation Processes in the Beverage and Food Industries (pages 227–266): Dan Donnelly, Joe Bergin, Tom Duane and Niall McNultyChapter 11 Recovery of Biological Products by Liquid Emulsion Membranes (pages 267–303): P. R. PatnaikChapter 12 Membranes Modified for Biochromatography (pages 305–326): Egbert Muller and Elias KleinChapter 13 Computer Modeling of Chromatographic Bioseparation (pages 327–362): Andreas Spieker, Ernst Kloppenburg and Ernst?Dieter GillesChapter 14 Neural Network Applications to Fermentation Processes (pages 363–409): P. R. PatnaikChapter 15 Advances in Modeling for Bioprocess Supervision and Control (pages 411–461): Andreas Lubbert and Rimvydas SimutisChapter 16 Validation of Viral Safety for Pharmaceutical Proteins (pages 463–496): Joachim K. Walter, Franz Nothelfer and William WerzChapter 17 Validation Issues in Chromatographic Processes (pages 497–511): Gail SoferChapter 1 Strategies in Downstream Processing (pages 1–30): Yusuf ChistiChapter 2 Protein Stability in Downstream Processing (pages 31–65): Kim Hejnaes, Finn Matthiesen and Lars SkriverChapter 3 Production of Transgenic Protein (pages 67–79): Gordon Wright and John NobleChapter 4 Harvesting Recombinant Protein Inclusion Bodies (pages 81–106): Anton P. J. Middelberg and Brian K. O'NeillChapter 5 The Application of Glycobiology for the Generation of Recombinant Glycoprotein Therapeutics (pages 107–129): Jan B. L. DammChapter 6 The Release of Intracellular Bioproducts (pages 131–164): Anton P. J. MiddelbergChapter 7 Microcarriers in Cell Culture Production (pages 165–222): Bjorn Lundgren and Gerald BlumlChapter 8 Purification and Characterization of Monoclonal Antibodies (pages 223–252): Paul Matejtschuk, Rose M. Baker and George E. ChapmanChapter 9 Biological Standardization of Interferons and Other Cytokines (pages 253–274): Anthony MeagerChapter 10 The Strategic Role of Assays in Process Development: A Case Study of Matrix?Assisted Laser Desorption Ionization Mass Spectroscopy as a Tool for Biopharmaceutical Development (pages 275–290): T. J. Meyers, P. G. Varley, A. Binieda, J. A. Purvis and N. R. BurnsChapter 11 Quality Control of Protein Primary Structure by Automated Sequencing and Mass Spectrometry (pages 291–323): Philip J. Jackson and Stephen J. BayneChapter 12 General Strategies for the Characterization of Carbohydrates from Recombinant Glycoprotein Therapeutics (pages 325–375): Gerrit J. Gerwig and Jan B. L. DammChapter 13 Biosafety (pages 377–415): Yusuf ChistiChapter 14 Process Hygiene in Production Chromatography and Bioseparation (pages 417–446): Glenwyn D. KempChapter 15 Strategies and Considerations for Advanced Economy in Downstream Processing of Biopharmaceutical Proteins (pages 447–460): Joachim K. Walter